Key result
Poliovirus infection of HeLa cells resulted in defective eIF3 activity, suggesting it or a co-purifying factor may be responsible for discriminating between cellular and viral mRNA translation.
The discrimination between cellular and viral mRNA translation in poliovirus-infected cells may be mediated by alterations in eIF3 or a co-purifying factor, rather than eIF4B.
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Helentjaris et al. (1979) studied Poliovirus infection. Poliovirus infection vs. Uninfected HeLa cells was evaluated on Initiation factor activity (eIF3 and eIF4B) and mRNA translation. Poliovirus infection of HeLa cells resulted in defective eIF3 activity, suggesting it or a co-purifying factor may be responsible for discriminating between cellular and viral mRNA translation.
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