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April 1, 1982Journal of VirologyOpen Access

Association of cap-binding protein with eucaryotic initiation factor 3 in initiation factor preparations from uninfected and poliovirus-infected HeLa cells

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Population

Uninfected and poliovirus-infected HeLa cells

Comparison

Poliovirus infection vs Uninfected HeLa cells

Design

Preclinical

Authors

JHJoanna HansenUniversity of UtahDED EtchisonUniversity of California, IrvineJHJohn W.B. HersheyRockefeller Foundation

Discussion

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Implication

May inform poliovirus translation shutoff mechanisms; hypothesis-generating for eIF-3 targeting in viral infections.

Structured PICO

P
Population
Uninfected and poliovirus-infected HeLa cells
I
Intervention
Poliovirus infection
C
Comparator
Uninfected HeLa cells
O
Outcome
Association of cap-binding protein (CBP) with eucaryotic initiation factor 3 (eIF-3)surrogate

Poliovirus infection disrupts the functional complex association of cap-binding protein with eIF-3 in HeLa cells.

Cite This Study

Hansen et al. (1982) studied this question.

synapsesocial.com/papers/6a894434a4df84145ecafcdfhttps://doi.org/10.1128/jvi.42.1.200-207.1982
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Purification of a factor that restores translation of vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells.1980 · 163 citations
  2. 2Specificity of initiation factor preparations from poliovirus-infected cells1980 · 13 citations
  3. 3Inhibition of translation by poliovirus: inactivation of a specific initiation factor.1978 · 200 citations
  4. 4Structural difference between the 5' termini of viral and cellular mRNA in poliovirus-infected cells: possible basis for the inhibition of host protein synthesis1976 · 120 citations
  5. 5Poliovirus-induced inhibition of polypeptide initiation in vitro on native polyribosomes.1976 · 69 citations