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May 1, 1990Journal of Biological ChemistryOpen Access

Variations in cap-binding complexes from uninfected and poliovirus-infected HeLa cells.

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Population

HeLa cells

Comparison

Poliovirus infection vs Uninfected HeLa cells

Design

Preclinical

Authors

DED EtchisonUniversity of California, IrvineKSKaren SmithUniversity of Louisiana at Lafayette

Discussion

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Implication

No immediate clinical application; leaves open whether eIF-3 targeting yields antiviral strategies.

Structured PICO

P
Population
HeLa cells
I
Intervention
Poliovirus infection
C
Comparator
Uninfected HeLa cells
O
Outcome
Polypeptide compositions of cap affinity-purified complexessurrogate

Poliovirus infection alters the composition of cap-binding complexes in HeLa cells, suggesting eIF-3 plays a direct role in cap binding and that p220 cleavage disrupts the eIF-4F/eIF-3 association.

Cite This Study

Etchison et al. (1990) studied this question.

synapsesocial.com/papers/6a82fe26c091764b21efdb83https://doi.org/10.1016/s0021-9258(19)39140-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The cap-binding protein complex in uninfected and poliovirus-infected HeLa cells.1987 · 66 citations
  2. 2Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus.1982 · 107 citations
  3. 3An RNA sequence of hundreds of nucleotides at the 5' end of poliovirus RNA is involved in allowing viral protein synthesis1988 · 173 citations
  4. 4An internal 5'-noncoding region required for translation of poliovirus RNA in vitro1988 · 80 citations
  5. 5A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation1988 · 1,377 citations