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May 1, 1992Journal of VirologyOpen Access

Relationship of eukaryotic initiation factor 3 to poliovirus-induced p220 cleavage activity

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Population

Poliovirus-infected and uninfected HeLa cells and in vitro assays

Comparison

Viral 2A protease and eukaryotic initiation… vs Uninfected cells / absence of eIF-3

Design

Preclinical

Authors

EWElizabeth E. WyckoffTroy UniversityRLRichard E. LloydUniversity of MinnesotaEEE EhrenfeldUniversity of Geneva

Discussion

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Implication

Does not support clinical translation; leaves open targeted validation in human models.

Structured PICO

P
Population
Poliovirus-infected and uninfected HeLa cells and in vitro assays
I
Intervention
Viral 2A protease and eukaryotic initiation factor 3 (eIF-3)
C
Comparator
Uninfected cells / absence of eIF-3
O
Outcome
Cleavage of the p220 subunit of eukaryotic initiation factor 4F (eIF-4F)surrogate

eIF-3 plays a crucial role in the p220 cleavage cascade subsequent to the 2Apro-induced activation of the p220-specific protease in poliovirus infection.

Cite This Study

Wyckoff et al. (1992) studied this question.

synapsesocial.com/papers/6a83446ecfe08b7fa662d57chttps://doi.org/10.1128/jvi.66.5.2943-2951.1992
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The p220 component of eukaryotic initiation factor 4F is a substrate for multiple calcium-dependent enzymes1990 · 18 citations
  2. 2Characterization of poliovirus 2A proteinase by mutational analysis: residues required for autocatalytic activity are essential for induction of cleavage of eukaryotic initiation factor 4F polypeptide p2201991 · 83 citations
  3. 3cis- and trans-cleavage activities of poliovirus 2A protease expressed in Escherichia coli1991 · 28 citations
  4. 4Poliovirus protease does not mediate cleavage of the 220,000-Da component of the cap binding protein complex.1985 · 38 citations
  5. 5Poliovirus protease 3C (P3-7c) does not cleave P220 of the eucaryotic mRNA cap-binding protein complex1985 · 28 citations