Population
HeLa cells infected by poliovirus / in vitro assay
Design
Preclinical
Authors
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Rules out direct 3C/2C role in P220 cleavage; leaves open the poliovirus factor mediating host shutoff.
Poliovirus proteins 3C and 2C are not directly responsible for the cleavage of P220 and the subsequent shut-off of host cellular protein synthesis.
Lee et al. (1985) studied this question.
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