May 1, 1985Proceedings of the National Academy of SciencesOpen Access

Poliovirus protease does not mediate cleavage of the 220,000-Da component of the cap binding protein complex.

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Population

HeLa cells infected with poliovirus

Design

Preclinical

Authors

RLRichard E. LloydUniversity of Minnesota DED EtchisonUniversity of California, Irvine EEE EhrenfeldUniversity of Geneva

Discussion

Member takes

Implication

Challenges attribution of p220 cleavage to 3C; leaves open identification of the mediating protease in infection models.

Structured PICO

Population

HeLa cells infected with poliovirus

Intervention

Analysis of viral protease (peptide 3C) and its role in p220 cleavage

Outcome

Cleavage activity of p220

The poliovirus protease (peptide 3C) is not the direct mediator of the cleavage of the 220,000-Da component of the cap binding protein complex during infection.

Cite This Study

Lloyd et al. (1985) studied this question.

synapsesocial.com/papers/6a8293bc576c5bd0156d0121 https://doi.org/10.1073/pnas.82.9.2723

View Full Paper

Ask AI

Bookmark

Poliovirus protease does not mediate cleavage of the 220,000-Da component of the cap binding protein complex.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Poliovirus protease does not mediate cleavage of the 220,000-Da component of the cap binding protein complex.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider