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October 1, 1990Biochemistry

The p220 component of eukaryotic initiation factor 4F is a substrate for multiple calcium-dependent enzymes

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Population

Extracts of uninfected HeLa cells

Design

Preclinical

Authors

EWElizabeth E. WyckoffTroy UniversityDCDorothy E. CroallUniversity of MaineEEEllie EhrenfeldNational Institutes of Health

Discussion

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Implication

Distinguishes host calcium-dependent p220 cleavage from poliovirus mechanisms; leaves open virus-specific pathways for eIF-4F disruption.

Structured PICO

P
Population
Extracts of uninfected HeLa cells
I
Intervention
Calcium exposure / calcium-dependent enzymes (calpains I and II, transglutaminase)
O
Outcome
Loss/cleavage of p220 component of eukaryotic initiation factor 4Fsurrogate

Identifies calcium-dependent enzymes (calpains I and II, and a transglutaminase) that cleave the p220 component of eIF-4F in uninfected HeLa cells, distinct from the mechanism in poliovirus-infected cells.

Cite This Study

Wyckoff et al. (1990) studied this question.

synapsesocial.com/papers/6a8d0628b27309dd08099c2dhttps://doi.org/10.1021/bi00495a007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship of eukaryotic initiation factor 3 to poliovirus-induced p220 cleavage activity1992 · 57 citations
  2. 2Eukaryotic initiation factor 3 is required for poliovirus 2A protease-induced cleavage of the p220 component of eukaryotic initiation factor 4F.1990 · 63 citations
  3. 3Variations in cap-binding complexes from uninfected and poliovirus-infected HeLa cells.1990 · 24 citations
  4. 4Cleavage of p220 by Purified Poliovirus 2Apro in Cell-Free Systems: Effects on Translation of Capped and Uncapped mRNAs1997 · 21 citations
  5. 5Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p2201987 · 322 citations