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June 1, 1978Proceedings of the National Academy of SciencesOpen Access

Inhibition of translation by poliovirus: inactivation of a specific initiation factor.

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Population

Extracts from poliovirus-infected and uninfected HeLa cells

Comparison

Addition of purified translation initiation… vs Uninfected HeLa cell extracts or extracts…

Design

Preclinical

Authors

JRJ K RoseUniversity of North Carolina at Chapel HillHTHans TrachselRutgers, The State University of New JerseyKLKelsey LeongUniversity of Washington

Discussion

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Implication

May inform antiviral strategies in viral cardiomyopathies; leaves open validation in cardiac models.

Structured PICO

P
Population
Extracts from poliovirus-infected and uninfected HeLa cells
I
Intervention
Addition of purified translation initiation factors (specifically eIF-4B) or mixing of infected and uninfected extracts
C
Comparator
Uninfected HeLa cell extracts or extracts without added factors
O
Outcome
Translation of vesicular stomatitis virus (VSV) mRNA and poliovirus mRNAsurrogate

Poliovirus inhibits host mRNA translation by inactivating the translation initiation factor eIF-4B.

Cite This Study

Rose et al. (1978) studied this question.

synapsesocial.com/papers/6a227e258a4701dbb79136aehttps://doi.org/10.1073/pnas.75.6.2732
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of Protein Synthesis in HeLa Cells1971 · 119 citations
  2. 2Structural difference between the 5' termini of viral and cellular mRNA in poliovirus-infected cells: possible basis for the inhibition of host protein synthesis1976 · 120 citations
  3. 3Cellular protein synthesis shutoff by mengovirus: translation of nonviral and viral mRNA's in extracts from uninfected and infected Ehrlich ascites tumor cells1976 · 56 citations
  4. 4The 5' end of poliovirus mRNA is not capped with m7G(5')ppp(5')Np.1976 · 277 citations
  5. 5Temperature-sensitive Poliovirus Mutants Defective in Repression of Host Protein Synthesis are also Defective in Structural Protein1973 · 29 citations