Key result
Poliovirus infection specifically inhibits the initiation of translation of host cell mRNA, while human cells respond by producing an actinomycin-sensitive factor antagonistic to this inhibition.
Population
HeLa cells (human cells)
Design
Preclinical
Authors
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Hypothesis-generating for viral translation shutdown; leaves open extension to cardiac viral pathogens.
This study elucidates the mechanism by which poliovirus inhibits host cell protein synthesis and identifies a host cell compensatory response.
Leibowitz et al. (1971) studied Poliovirus infection. Poliovirus infection was evaluated on Inhibition of host cell protein synthesis. Poliovirus infection specifically inhibits the initiation of translation of host cell mRNA, while human cells respond by producing an actinomycin-sensitive factor antagonistic to this inhibition.
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