Poliovirus infection specifically inhibits the initiation of translation of host cell mRNA, while human cells respond by producing an actinomycin-sensitive factor antagonistic to this inhibition.
This study elucidates the mechanism by which poliovirus inhibits host cell protein synthesis and identifies a host cell compensatory response.
The mechanism of inhibition of host cell protein synthesis by poliovirus has been studied by examining the behavior of host polyribosomes and polyribosome-associated messenger ribonucleic acid (mRNA). Virus infection appears to result in a specific inhibition of the initiation of translation of host cell mRNA. The site of inhibition does not appear to be mRNA itself. Human cells respond to virus infection by producing a factor antagonistic to the virus inhibition which promotes the initiation of host mRNA translation. The production of the host factor is sensitive to actinomycin; however, the behavior of the host cell factor and that of host mRNA appear distinctly different.
Leibowitz et al. (Mon,) conducted a other in Poliovirus infection. Poliovirus infection was evaluated on Inhibition of host cell protein synthesis. Poliovirus infection specifically inhibits the initiation of translation of host cell mRNA, while human cells respond by producing an actinomycin-sensitive factor antagonistic to this inhibition.