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May 1, 1971Proceedings of the National Academy of SciencesOpen Access

Double-Stranded Poliovirus RNA Inhibits Initiation of Protein Synthesis by Reticulocyte Lysates

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Population

HeLa cells infected with poliovirus and rabbit reticulocyte lysates

Design

Preclinical

Authors

EEEllie EhrenfeldNational Institutes of HealthTHTim HuntTwitter (United States)

Discussion

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Implication

May mediate poliovirus host shutoff; leaves open in vivo relevance and clinical translation.

Structured PICO

P
Population
HeLa cells infected with poliovirus and rabbit reticulocyte lysates
I
Intervention
Poliovirus double-stranded RNA
O
Outcome
Inhibition of initiation of protein synthesis in vitrosurrogate

Poliovirus double-stranded RNA is identified as the agent responsible for inhibiting host-cell protein synthesis initiation.

Cite This Study

Ehrenfeld et al. (1971) studied this question.

synapsesocial.com/papers/6a6ff37bfebe604dd708c47dhttps://doi.org/10.1073/pnas.68.5.1075
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Purification and Characterization of Poliovirus-induced Infectious Double-stranded Ribonucleic Acid1967 · 113 citations
  2. 2Characterization of ribonuclease-resistant RNA from poliovirus-infected HeLa cells.1965 · 46 citations
  3. 3Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells.1965 · 362 citations
  4. 4POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA1963 · 469 citations
  5. 5FACTORS AFFECTING PROTEIN SYNTHESIS IN VITRO IN RABBIT RETICULOCYTES1957 · 222 citations