Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 1976Journal of General Virology

Inhibition of Protein Synthesis in Reticulocyte Lysates by Poliovirus

View Full Paper
Ask AI
Bookmark
Share

Population

Rabbit reticulocyte lysate protein synthesizing system (100 mul)

Design

Preclinical

Authors

JRJanis RacevskisMontefiore Medical CenterSKS.S. KerwarNovartis (Switzerland)GKGebhard KochRoche (Switzerland)

Discussion

Loading...

Member takes

Implication

Viral coat protein may inhibit translation initiation; leaves open relevance to intact cells or infection models.

Structured PICO

P
Population
Rabbit reticulocyte lysate protein synthesizing system (100 mul)
I
Intervention
Addition of 1 X 10(10) p.f.u. purified poliovirus
O
Outcome
Inhibition of initiation of protein synthesissurrogate

Purified poliovirus, likely via its coat protein, completely inhibits the initiation of protein synthesis in a rabbit reticulocyte lysate system.

Cite This Study

Racevskis et al. (1976) studied this question.

synapsesocial.com/papers/6a825747477bdf2e97a20cf6https://doi.org/10.1099/0022-1317-31-1-135
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Double-Stranded Poliovirus RNA Inhibits Initiation of Protein Synthesis by Reticulocyte Lysates1971 · 203 citations
  2. 2In vitro translation of poliovirus RNA: utilization of internal initiation sites in reticulocyte lysate1984 · 235 citations
  3. 3Poliovirus-induced inhibition of polypeptide initiation in vitro on native polyribosomes.1976 · 69 citations
  4. 4I. The Inhibition of Cellular Protein Synthesis in HeLa Cells after Infection with Active and Inactivated Poliovirus1971 · 7 citations
  5. 5Effect of Poliovirus Double-Stranded RNA on Viral and Host-Cell Protein Synthesis1974 · 47 citations