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Demonstrates that an intact poliovirus genome and de novo protein synthesis are required for the virus to inhibit host cellular protein synthesis in HeLa cells.
Evidence is presented that the genome of the infecting poliovirus must be intact in order to achieve inhibition of cellular protein synthesis. Viral particles with a single lethal hit by treatment with hydroxylamine no longer participate in the inhibitory action of the virus. De novo protein synthesis is required for the inhibition to occur. The synthesis of cellular m-RNA is not necessary.
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Koschel et al. (1971) studied this question.
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