Key result
Human lymphoblastoid interferon treatment of poliovirus-infected HeLa cells inhibits protein synthesis without causing gross degradation of cellular RNA.
Why the study?
Does interferon treatment cause degradation of cellular RNA in poliovirus-infected HeLa cells?
Population
HeLa cells infected with poliovirus
Comparison
Human lymphoblastoid interferon treatment vs Poliovirus-infected cells without interferon…
Design
Preclinical
Authors
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Excludes gross RNA degradation as interferon mechanism in this model; leaves open targeted translational pathways for further study.
Does interferon treatment cause degradation of cellular RNA in poliovirus-infected HeLa cells?
Inhibition of protein synthesis in interferon-treated poliovirus-infected HeLa cells is not caused by gross degradation of cellular RNA by a non-specific nuclease.
Múñoz et al. (1983) studied Poliovirus infection in HeLa cells. Human lymphoblastoid interferon vs. No interferon treatment was evaluated on Degradation of cellular RNA and inhibition of protein synthesis. Human lymphoblastoid interferon treatment of poliovirus-infected HeLa cells inhibits protein synthesis without causing gross degradation of cellular RNA.
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