Key result
High-voltage stimulus prolongs induced AF duration ~13-fold vs. low-voltage pacing in hypertensive rats.
Why the study?
Does high voltage stimulus increase the duration of electrically induced atrial fibrillation in hypertensive rats compared to low voltage stimulus?
Does high voltage stimulus increase the duration of electrically induced atrial fibrillation in hypertensive rats compared to low voltage stimulus?
High-voltage electrical stimulation augments atrial fibrillation duration in hypertensive rats, suggesting that interacting structural and electrophysiological factors in hypertension exacerbate atrial fibrillation.
High-voltage AF prolongation in hypertensive rats should not change practice; hypothesis-generating for voltage effects, translational studies needed.
Objective. Many previous clinical studies have suggested that atrial fibrillation (AF) is closely associated with hypertension. However, the benefits of antihypertensive therapy on AF are still inconsistent, and it is necessary to explore the factors augmenting AF in hypertensive rats. The aim of the present study was to investigate the correlation between arterial pressure or voltage stimulus and to the duration of electrically induced AF in normotensive or hypertensive rats. Methods. AF was reproducibly induced by transesophageal atrial burst pacing in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). We did the burst pacing at high (20 V) or low (5 V) voltage. Results. Duration of AF did not correlate with systolic blood pressure (SBP) and stimulus voltage in WKY. However, only in SHR, duration of AF with high stimulus voltage significantly correlated with SBP and was significantly longer in high than in low voltage stimulus. Discussion and Conclusion. Duration of AF is augmented by high voltage stimulus with higher blood pressure in SHR.
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Nagayama et al. (2014) studied Hypertension and Atrial Fibrillation (n=8). High voltage transesophageal atrial burst pacing vs. Low voltage transesophageal atrial burst pacing was evaluated on Duration of electrically induced atrial fibrillation in spontaneously hypertensive rats (p=<0.01). High voltage stimulus significantly increased the duration of induced atrial fibrillation compared to low voltage stimulus in spontaneously hypertensive rats (19.3 vs 1.5 seconds, p<0.01).
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