Key result
NIDDM patients with and without diabetic nephropathy had a significantly higher prevalence of left ventricular hypertrophy (75% and 51%, respectively) compared to non-diabetic controls (9%, p<0.001).
Why the study?
Does NIDDM with or without diabetic nephropathy increase left ventricular mass index and the prevalence of left ventricular hypertrophy compared to non-diabetic controls?
Population
126 subjects: 51 NIDDM patients with diabetic nephropathy, 53 NIDDM patients with normoalbuminuria, and 22…
Comparison
Non-insulin-dependent diabetes mellitus with or… vs Non-diabetic control subjects
Design
Case-control
Authors
Loading...
NIDDM may warrant echocardiographic monitoring independent of nephropathy; hypothesis-generating for diabetic cardiomyopathy mechanisms.
Case-Control (n=126)
Does NIDDM with or without diabetic nephropathy increase left ventricular mass index and the prevalence of left ventricular hypertrophy compared to non-diabetic controls?
Absolute Event Rate: 75% vs 9%
p-value: p=<0.001
NIDDM patients, regardless of nephropathy status or hypertension, have a significantly higher prevalence of left ventricular hypertrophy and reduced systolic function compared to non-diabetic controls.
Nielsen et al. (1997) conducted a case-control in Non-insulin-dependent Diabetes Mellitus (NIDDM) with and without diabetic nephropathy (n=126). NIDDM with or without diabetic nephropathy vs. Non-diabetic control subjects was evaluated on Prevalence of left ventricular hypertrophy (LVH) (p=<0.001). NIDDM patients with and without diabetic nephropathy had a significantly higher prevalence of left ventricular hypertrophy (75% and 51%, respectively) compared to non-diabetic controls (9%, p<0.001).