Key result
Normotensive T2DM linked to ~34% higher LVMI versus nondiabetic controls.
Why the study?
Left ventricular hypertrophy is often present in type 2 DM patients and is an independent risk factor for cardiac events, but its prevalence in normotensive type 2 diabetic patients without antihypertensive medication was unclear.
Does type 2 diabetes mellitus increase left ventricular mass in normotensive patients compared to nondiabetic controls?
Cross-Sectional (n=130)
Does type 2 diabetes mellitus increase left ventricular mass in normotensive patients compared to nondiabetic controls?
Absolute Event Rate: 104.9% vs 78.5%
p-value: p=< 0.05
Normotensive patients with type 2 diabetes have significantly higher left ventricular mass index compared to nondiabetic controls, which is associated with BMI, HbA1c, and diabetes duration.
Highlights potential early LV remodeling in normotensive T2DM; hypothesis-generating and should not yet change practice.
Cardiovascular disease is increased in individuals with type 1 or type 2 diabetes mellitus (DM). Left ventricular hypertrophy (LVH), which is an ominous prognostic sign and an independent risk factor for cardiac events, is often present in type 2 DM patients. The aim of our cross-sectional study was to evaluate the prevalence of LVH, and risk factors for its development, in normotensive type 2 diabetic patients without antihypertensive medication. The objectives of the study were to find out the prevalence of high left ventricular mass (LVM) in normotensive type 2 diabetic patients and compare it with nondiabetics and to uncover the risk factors for the development of high LVM in normotensive type 2 diabetic patients. A total of 130 age- and sex-matched subjects were selected (65 cases, diabetic normotensive, and 65 controls, nondiabetic normotensive) and baseline data were collected. LVM and left ventricular mass index (LVMI) were calculated using echocardigraphic parameters and body surface area. LVMI was significantly higher in patients with type 2 DM compared with age-, sex-matched healthy population (104.9 ± 21 vs. 78.5 ± 22.7 g/m(2), respectively; P < 0.05). BMI, HbA1c, and duration of diabetes were significantly associated with LVH whereas sexes, age, PPBS, were not.
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Santra et al. (2011) conducted a cross-sectional in Normotensive type 2 diabetes mellitus (n=130). Type 2 diabetes mellitus vs. Nondiabetic normotensive controls was evaluated on Left ventricular mass index (LVMI) (p=< 0.05). Normotensive type 2 diabetes mellitus was associated with a significantly higher left ventricular mass index compared with nondiabetic controls (104.9 vs. 78.5 g/m2; P < 0.05).
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