Key result
Insulin sensitivity was inversely related to left ventricular wall thickness (r = -0.59, P < 0.0001), explaining 43% of its variation in patients with untreated hypertension.
Why the study?
Is left ventricular hypertrophy associated with insulin resistance in patients with untreated hypertension?
Population
50 patients with untreated hypertension
Design
Cross-sectional
Follow-up
4-6 weeks (placebo run-in)
Authors
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Supports insulin resistance-LVH link beyond BP in untreated hypertension; hypothesis-generating, requiring prospective trials before practice change.
Cross-Sectional (n=50)
Is left ventricular hypertrophy associated with insulin resistance in patients with untreated hypertension?
Effect estimate: r = -0.59
p-value: p=<0.0001
In patients with hypertension, left ventricular hypertrophy and diastolic dysfunction are strongly associated with insulin resistance, independent of blood pressure levels.
Lind et al. (1995) conducted a cross-sectional in untreated hypertension (n=50). Insulin sensitivity was evaluated on Left ventricular wall thickness (r = -0.59, p=<0.0001). Insulin sensitivity was inversely related to left ventricular wall thickness (r = -0.59, P < 0.0001), explaining 43% of its variation in patients with untreated hypertension.