Key result
Higher mean cumulative clinic diastolic blood pressure was a strong independent predictor of diabetic retinopathy development or progression, with a 36% increased risk per 1-SD increment (HR 1.36).
Why the study?
What are the independent predictors of development or progression of diabetic retinopathy in high-risk patients with type 2 diabetes?
Cohort (n=544)
No
What are the independent predictors of development or progression of diabetic retinopathy in high-risk patients with type 2 diabetes?
Hazard Ratio: 1.36 (95% CI 1.14–1.61)
p-value: p=0.001
In high-risk patients with type 2 diabetes, longer diabetes duration, poorer glycemic and lipid control, and higher blood pressures (especially clinic diastolic BP) independently predict the development and progression of diabetic retinopathy.
No takes yet. Share an insight, caveat, or question.
May inform closer retinopathy surveillance in T2D; extends cumulative exposure associations but leaves open whether optimization alters progression.
Cardoso et al. (2017) conducted a cohort in Type 2 Diabetes (n=544). Higher mean cumulative clinic diastolic blood pressure vs. Lower mean cumulative clinic diastolic blood pressure was evaluated on Development or progression of diabetic retinopathy (HR 1.36, 95% CI 1.14-1.61, p=0.001). Higher mean cumulative clinic diastolic blood pressure was a strong independent predictor of diabetic retinopathy development or progression, with a 36% increased risk per 1-SD increment (HR 1.36).
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