Key result
Obesity in adolescents and young adults was associated with paradoxically lower arterial stiffness (CAVI 4.59 vs 5.18) and lower systemic vascular resistance compared to non-obese controls.
Why the study?
Studies assessing early atherosclerosis indices CAVI and RHI in obesity have yielded paradoxical and differing results.
Does obesity alter early atherosclerosis indices like arterial stiffness (CAVI) and endothelial function (RHI) in adolescents and young adults?
Cross-Sectional (n=58)
No
Does obesity alter early atherosclerosis indices like arterial stiffness (CAVI) and endothelial function (RHI) in adolescents and young adults?
Absolute Event Rate: 4.59% vs 5.18%
p-value: p=0.002
In young obese patients, paradoxically lower arterial stiffness (CAVI) is driven by decreased systemic vascular resistance rather than true vascular health, highlighting the confounding effect of vascular tone on early atherosclerosis indices.
May signal early autonomic vascular changes in obese youth; leaves open causal links to atherosclerosis progression.
AIM: Motivated by the paradoxical and differing results of the early atherosclerosis related indices - Cardio-Ankle Vascular Index (CAVI) reflecting arterial stiffness and Reactive Hyperemia Index (RHI) evaluating endothelium dependent flow-induced vasodilation - in obesity, we aimed to assess CAVI and RHI in obese adolescents and young adults in the context of differences in systemic vascular resistance (SVR). METHODS: (spectral power in low frequency band of systolic blood pressure oscillations) were determined. RESULTS: (6.46±1.39 vs.7.33±0.99, p=0.002) were significantly lower. No significant difference in RHI was found. SVR and sympathetic activity indices were all significantly lower in the obese group than in the non-obese group. RHI correlated positively with SVR (r=0.390, p=0.044) in obese subjects. CONCLUSION: Our results indicate that both indices used for the detection of early atherosclerotic changes are influenced by vascular tone. Vascular resistance could influence CAVI and RHI results impairing their interpretation.
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Czippelová et al. (2019) conducted a cross-sectional in Obesity (n=58). Obesity vs. Non-obese controls was evaluated on Cardio-Ankle Vascular Index (CAVI) (p=0.002). Obesity in adolescents and young adults was associated with paradoxically lower arterial stiffness (CAVI 4.59 vs 5.18) and lower systemic vascular resistance compared to non-obese controls.
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