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June 28, 2026Harran Üniversitesi Veteriner Fakültesi DergisiOpen Access

Evaluation of the Protective Effects of Arbutin Via Hormonal, Anti-Inflammatory, and Antioxidant Pathways in Experimental Sepsis Induced Ovarian Damage

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Authors

GUG. UyanıkİGİshak GökçekMAMurat Abay

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Overview

Randomized trial evaluates arbutin's protective effects on ovarian damage in rats, suggesting potential for recovery.

Key Points

  • This study aims to assess the protective effects of arbutin against sepsis-induced ovarian damage, evaluating both prophylactic and post-sepsis administration.
  • Forty-nine female Wistar albino rats were randomly assigned to seven treatment groups.
  • Sepsis was induced using cecal puncture, and arbutin was administered orally in different protocols.
  • Serum hormone levels and ovarian tissue concentrations of inflammatory and oxidative markers were measured post-treatment.
  • Sepsis significantly decreased serum AMH and estradiol levels and increased TNF-α, IL-6, and MDA.
  • Arbutin treatment improved GSH levels and reduced TNF-α, IL-6, and MDA concentrations compared to the sepsis group.
  • Both doses (50 and 100 mg/kg) of arbutin showed similar protective effects, indicating a dose-independent response.

Cite This Study

Uyanık et al. (2026) studied this question.

synapsesocial.com/papers/6a40b96161bb0a67205c5abbhttps://doi.org/10.31196/huvfd.1902306
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