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September 18, 2025Biomolecules and BiomedicineOpen Access

Arbutin as a potential nephroprotective agent: Dose-related effects in renal ischemia-reperfusion injury

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Authors

FŞFerhat ŞirinyıldızIKIzel KavakNÇNesibe Kahraman Çetin

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Overview

This study demonstrates arbutin's ability to reduce oxidative stress and inflammation in nephroprotection, suggesting its therapeutic potential.

Key Points

  • Arbutin significantly reduces key markers of oxidative stress and inflammation in renal ischemia-reperfusion injury.
  • The AR1000+IRI group showed the most notable improvement, reducing markers like malondialdehyde and tumor necrosis factor alpha.
  • Animal study involving 24 male Wistar albino rats assessed arbutin's protective effects against renal damage.
  • These findings support arbutin's potential role in preventing kidney injury during ischemic events.

Cite This Study

Şirinyıldız et al. (2025) studied this question.

synapsesocial.com/papers/68d46ccf31b076d99fa692c1https://doi.org/10.17305/bb.2025.13056
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