Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 28, 2026Drug Development and Industrial Pharmacy

Synergistic Anticancer Potential of Andrographolide and Paclitaxel: A Dose-Reduction Strategy to Minimize Toxicity and Enhance Therapeutic Efficacy

View Full Paper
Ask AI
Bookmark
Share

Authors

RSRomi SinghAmerican Association of Colleges of PharmacyPYP Yadunandan YadavNorthwestern UniversityDSDipti SrivastavaCentral Drug Research Institute

Discussion

Loading...

Member takes

Implication

Randomized trial examines combined Andrographolide and Paclitaxel for enhanced cancer treatment, suggesting reduced toxicity.

Key Points

  • This study aims to evaluate the combined anticancer efficacy of Andrographolide and Paclitaxel to improve therapeutic outcomes while minimizing toxicity.
  • Cytotoxicity assessed using Chou-Talalay method for various concentrations of AG and PTX.
  • Nanoemulsion optimized for particle size, zeta potential, and encapsulation efficiency.
  • In vivo efficacy tested using a syngeneic tumor mouse model to assess tumor regression and safety.
  • AG-PTX nanoemulsion showed enhanced cellular uptake and apoptosis compared to monotherapies.
  • Significant tumor regression observed (10-fold) in mouse model with stable body weight indicating reduced toxicity.
  • Therapeutic efficacy confirmed through various cellular tests and histopathological analysis.

Cite This Study

Singh et al. (2026) studied this question.

synapsesocial.com/papers/6a40b9c461bb0a67205c5d9fhttps://doi.org/10.1080/03639045.2026.2696023
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An update on breast cancer chemotherapy-associated toxicity and their management approaches2023 · 29 citations
  2. 2Nanoemulsion: for improved oral delivery of repaglinide2015 · 82 citations
  3. 3Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation2015 · 78 citations
  4. 4Cinnamon Oil Nanoemulsion Formulation by Ultrasonic Emulsification: Investigation of Its Bactericidal Activity2013 · 203 citations
  5. 5The new era of nanotechnology, an alternative to change cancer treatment2017 · 200 citations