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June 1, 2026Open Access

Synergistic induction of apoptosis in cancer cells by combined silver nanoparticles and paclitaxel.

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Authors

ASAlireza ShamsJahrom University of Medical SciencesMSMunjiba ShamsIran University of Medical SciencesMAMaryam AmirinejadJahrom University of Medical Sciences

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Implication

Randomized trial shows enhanced cell death in cervical cancer with paclitaxel and silver nanoparticles, indicating improved treatment potential.

Key Points

  • This research aims to evaluate the combined effects of paclitaxel and silver nanoparticles on cervical cancer cells to enhance anti-cancer activity.
  • MTT assay was used to assess anti-cancer activity of PTX and PTX-AgNPs.
  • Real-time PCR evaluated expression levels of apoptotic and anti-apoptotic markers.
  • Comparative analysis of treatment effects against control cells was performed.
  • The combination of PTX with AgNPs significantly increased apoptosis compared to PTX alone (P<0.05).
  • Levels of anti-apoptotic Bcl-2 and Mcl-1 mRNA were decreased in all treated groups compared to controls.
  • Lower concentrations of PTX were required to achieve higher cell death rates in the combined treatment group.

Cite This Study

Shams et al. (2026) studied this question.

synapsesocial.com/papers/6a1d21ba02fbce9130637adahttps://doi.org/10.22038/ijbms.2026.90764.19567
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Also Consider

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