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May 15, 2024Cancer Plus

Combination therapy of cisplatin and green silver nanoparticles enhances cytotoxicity and apoptosis in breast cancer cells

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Authors

MMMostafa Heidari Majd

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Overview

In vitro study demonstrates enhanced cytotoxicity and apoptosis in breast cancer cells treated with cisplatin and green silver nanoparticles, suggesting reduced drug resistance.

Key Points

  • Combining cisplatin with green silver nanoparticles enhances apoptosis and reduces the IC50 value up to 26-fold in MCF-7 cells, overcoming standard drug resistance.
  • In vitro assays show the combination therapy elevates the BAK1/BCLX ratio by 162-fold and boosts CASP3 expression by 273 times compared to cisplatin treatment alone.
  • Findings reveal suppressed AKT1 expression in MCF-7 cells, supporting natural nanoparticle adjuvants; cell culture model, further preclinical validation is required.

Cite This Study

Mostafa Heidari Majd (2024) studied this question.

synapsesocial.com/papers/68e69fffb6db643587623b33https://doi.org/10.36922/cp.2770
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