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September 28, 2025ACS NanoOpen Access

Exploring the Potentials of Silver Nanoparticles in Overcoming Cisplatin Resistance in Lung Adenocarcinoma: Insights from Proteomic and Xenograft Mice Studies

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Authors

TWTin Yan WongYWYan WangKKKenneth Kin Leung Kwan

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Overview

Quantitative proteomics reveals silver nanoparticles induce apoptosis in drug-resistant lung cells, suggesting potential therapy implications.

Key Points

  • Silver nanoparticles effectively induce apoptosis in both cisplatin-sensitive and resistant lung adenocarcinoma cells.
  • Cytotoxic effects of silver nanoparticles were similar across both A549 and A549/DDP cell lines, indicating broad applicability.
  • Proteomic analyses showed distinct responses in cellular pathways, particularly in RNA metabolism and VEGF signaling.
  • Xenograft studies confirmed that silver nanoparticles displayed consistent antitumoral effects in vivo, regardless of cisplatin sensitivity.

Cite This Study

Wong et al. (2025) studied this question.

synapsesocial.com/papers/68d9052941e1c178a14f585chttps://doi.org/10.1021/acsnano.5c09056
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