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June 28, 2026Metallomics

The Cancer Metallome Continuum: A Framework for Understanding Metal Dysregulation from Carcinogenesis to Therapeutic Resistance

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Authors

MMM. MokhtarMMM. MokhtarJSJassy Salim

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Overview

Review demonstrates a framework for metal dysregulation from cancer initiation to treatment resistance, implying essential roles in therapy outcomes.

Key Points

  • This review aims to outline the Cancer Metallome Continuum framework, focusing on metal dysregulation from carcinogenesis to therapeutic resistance.
  • Introduced the Cancer Metallome Continuum (CMC) framework to illustrate metallomic changes through cancer progression.
  • Evaluated analytical and translational approaches for integrating metallomics into oncology.
  • Discussed advances like selenium-based prognostic panels and copper-chelation trials.
  • Presented compelling evidence supporting selenium-based prognostic panels in breast and colorectal cancers.
  • Noted the adaptability of tumors through altered metal transporter expression under therapeutic pressure.
  • Highlighted ongoing developments in AI/ML applications for spatially resolved metallodrug imaging.

Cite This Study

Mokhtar et al. (2026) studied this question.

synapsesocial.com/papers/6a40b9f361bb0a67205c6080https://doi.org/10.1093/mtomcs/mfag024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of metals in cancer and the use of metal chelators as a potential treatment strategy2026
  2. 2Trace elements and tumors: homeostatic networks, molecular mechanisms and new horizons for precision intervention2026
  3. 3Metal‐Based Combination Therapies in Cancer: Mechanistic Principles and Emerging Opportunities2026
  4. 4Modulation of the PD-1/PD-L1 axis and tumor immunity by metals and metalloids: mechanistic insights and human health implications2026
  5. 5Molecular mechanisms of heavy metal-induced cancer: Insights from animal models and human implications2026