Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 28, 2026PLoS ONEOpen Access

Neuroprotective mechanisms of Thai traditional brain tonic Phy-Blica-O against LPS-induced neuroinflammation: Inhibition of NF-κB in microglia and mice

View Full Paper
Ask AI
Bookmark
Share

Authors

TKThammarat KaewmaneePrince of Songkla UniversityPGPalanivel GanesanKonkuk UniversityPCPiyapong ChoochanaRangsit University

Discussion

Loading...

Member takes

Overview

Randomized trial demonstrates neuroprotection in mice with LPS-induced neuroinflammation, suggesting therapeutic potential of Phy-Blica-O.

Key Points

  • This study investigates the neuroprotective mechanisms of Phy-Blica-O (PBO) against LPS-induced neuroinflammation.
  • PBO was tested in vitro on BV-2 microglial cells and in vivo on male C57BL/6J mice.
  • Inflammatory mediators and cytokines were measured at both mRNA and protein levels.
  • Cytokine expression and NF-κB signaling were evaluated using various quantitative assays.
  • PBO significantly reduced nitric oxide levels from 15.69 to 8.74 µM (p < 0.001).
  • PBO decreased pro-inflammatory cytokine mRNA expression: TNF-α by 25%, IL-1β by 31%, IL-6 by 19% (p < 0.05).
  • In vivo, oral PBO reduced iNOS and COX-2 mRNA levels (p = 0.041 and p = 0.018 respectively).

Cite This Study

Kaewmanee et al. (2026) studied this question.

synapsesocial.com/papers/6a40ba2161bb0a67205c6242https://doi.org/10.1371/journal.pone.0352429
View Full Paper
Ask AI
Bookmark
Share