Features and Clinical Significance of C-X-C Chemokine Receptor Type 4 Expression in Breast Cancer: A Prospective, Single-center Cohort Study

Q: What does this research mean for the field?

CXCR4 expression exhibits distinct clinical features and holds clinical significance in patients with breast cancer. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

M. A. Senchukova; Natalia Saidler

doi:10.61474/ncs.2026.00013

June 26, 2026Nature Cell and ScienceOpen Access

Features and Clinical Significance of C-X-C Chemokine Receptor Type 4 Expression in Breast Cancer: A Prospective, Single-center Cohort Study

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Key Points

The study aims to evaluate the expression of CXCR4 in breast cancer and its clinical implications.
Conducted as a single-center prospective cohort study.
Examined the expression of CXCR4 in breast cancer cells under various stimuli.
Assessed the role of CXCR4 in tumor proliferation, metastasis, and immune evasion.
CXCR4 expression increased significantly with exposure to hypoxia and various growth factors.
Higher CXCR4 levels correlating with tumor progression and metastasis.
Found association with poor patient outcomes, indicating potential for targeted therapies.

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Implication

Prospective cohort study examines CXCR4's role in breast cancer proliferation and metastasis, suggesting potential therapeutic targets.

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Cite This Study

Senchukova et al. (2026) studied this question.

synapsesocial.com/papers/6a40bab961bb0a67205c68d6 https://doi.org/10.61474/ncs.2026.00013

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Features and Clinical Significance of C-X-C Chemokine Receptor Type 4 Expression in Breast Cancer: A Prospective, Single-center Cohort Study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Features and Clinical Significance of C-X-C Chemokine Receptor Type 4 Expression in Breast Cancer: A Prospective, Single-center Cohort Study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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