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June 28, 2026SchizophreniaOpen Access

Stressful life events and their association with symptom severity and functioning in first-episode psychosis

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Authors

STStefania TogninМММарія МорозAAAljawharah Almuqrin

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Overview

Randomized trial examines symptom severity, functioning, and relapse in first-episode psychosis, suggesting the need for early intervention strategies.

Key Points

  • This study aims to evaluate the impact of stressful life events on symptom severity and functioning in individuals experiencing first-episode psychosis.
  • Longitudinal data analysis from the social mind study (ISRCTN85485447) involving 265 first-episode psychosis participants.
  • Assessment of associations between baseline stressful life events and clinical outcomes over a 1-year follow-up.
  • Statistical models adjusted for age, sex, ethnicity, and site.
  • Greater baseline exposure to stressful life events predicted more severe general psychopathology at follow-up (p < 0.05).
  • Higher baseline stressful life events correlated with poorer functioning across assessment timepoints (p < 0.05).
  • No significant association found between baseline stressful life events and increased odds of relapse.

Cite This Study

Tognin et al. (2026) studied this question.

synapsesocial.com/papers/6a40bae361bb0a67205c698ehttps://doi.org/10.1038/s41537-026-00778-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stressful Life Events and Suicidality in First‐Episode Psychosis2026
  2. 2Psychosocial stress moderates the relationship between cerebrospinal fluid lactate dehydrogenase and the duration of untreated psychosis in first-episode psychosis2024 · 1 citations
  3. 3Stress exposure prior to diagnosis and clinical characteristics in systemic lupus erythematosus: a cross-sectional study2026
  4. 4Relation between childhood trauma and social vulnerability in adulthood in patients with first episode psychosis2025
  5. 5Life events and their subjective appraisal by children and adolescents in clinical high-risk states of psychosis: a cross-sectional comparison with inpatients with non-psychotic disorders and community subjects2026