What question did this study set out to answer?

This study aims to investigate the association between retinal features measured by optical coherence tomography and cardiovascular risk in individuals with cardiovascular–kidney–metabolic syndrome stages 0–3.

June 28, 2026PLoS ONEOpen Access

Association between optical coherence tomography–quantified retinal features and cardiovascular risk in cardiovascular–kidney–metabolic syndrome stages 0–3: An analysis of a prospective UK biobank cohort

View Full Paper

Ask AI

Bookmark

This study aims to investigate the association between retinal features measured by optical coherence tomography and cardiovascular risk in individuals with cardiovascular–kidney–metabolic syndrome stages 0–3.
Prospective analysis of 40,516 UK Biobank participants with CKM syndrome stages 0–3 and available retinal OCT data
Utilized Cox regression and predictive metrics (NRI, IDI, AUC) to assess associations and prognostic value
Follow-up median duration of 14.6 years to observe cardiovascular outcomes
Thinner retinal nerve fiber layer (RNFL) and reduced macular thickness were independently linked to increased risks of incident cardiovascular disease and mortality (P < 0.001)
Significant linear dose–response relationships were established for retinal features and cardiovascular outcomes
Incorporating OCT-derived markers improved risk classification and discrimination (all P < 0.001)

Authors

CLChenhao LiJilin University SJSixiang JiaThe Fourth People's Hospital YYYang YangThe Fourth People's Hospital

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Prospective study finds retinal OCT features predict cardiovascular outcomes in CKM syndrome stages 0–3, suggesting early interventions may be beneficial.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a40bae361bb0a67205c6ad8 https://doi.org/10.1371/journal.pone.0351945

View Full Paper

Ask AI

Bookmark

Implication

Prospective study finds retinal OCT features predict cardiovascular outcomes in CKM syndrome stages 0–3, suggesting early interventions may be beneficial.

Association between optical coherence tomography–quantified retinal features and cardiovascular risk in cardiovascular–kidney–metabolic syndrome stages 0–3: An analysis of a prospective UK biobank cohort

Key Points

Discussion

Implication

Cite This Study

Association between optical coherence tomography–quantified retinal features and cardiovascular risk in cardiovascular–kidney–metabolic syndrome stages 0–3: An analysis of a prospective UK biobank cohort

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider