What does this research mean for the field?

Advanced chronic kidney disease (stages 3-5) is independently associated with significant thinning of multiple inner and photoreceptor-related macular retinal layers compared to early-stage disease, suggesting these metrics can serve as noninvasive indicators of systemic microvascular burden. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to examine the relationship between the severity of chronic kidney disease and retinal structural differences as measured by optical coherence tomography.

August 6, 2026BioData MiningOpen Access

Optical coherence tomographic retinal differences across stages of chronic kidney disease

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Authors

SGSamit Kumar GhoshKhalifa University of Science and Technology RMRizwan MalikKing Khaled Eye Specialist Hospital AKAhsan H. KhandokerElectrophysiology

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Implication

Cross-sectional study investigates retinal thinning in chronic kidney disease, linking it to systemic microvascular involvement.

Key Points

The study aims to examine the relationship between the severity of chronic kidney disease and retinal structural differences as measured by optical coherence tomography.
Cross-sectional study involving 1,515 participants with chronic kidney disease from the UK Biobank.
Participants classified into CKD stages 1-2 and 3-5 following KDIGO guidelines.
Linear mixed-effects models analyzed associations between CKD stage and retinal thickness, controlling for various physiological factors.
CKD stage 3-5 showed significant thinning of multiple retinal layers, including INL-ELM (β = -1.52µm) and INL-RPE (β = -2.57µm), all with FDR-adjusted p < 0.05.
Pronounced thinning was observed across most parafoveal and many perifoveal sectors.
No significant associations were found for ELM-IS OS thickness and central macular thickness after correction.

Cite This Study

Ghosh et al. (2026) studied this question.

synapsesocial.com/papers/6a7437e1764cddc9499d5ab2 https://doi.org/10.1186/s13040-026-00592-8

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Optical coherence tomographic retinal differences across stages of chronic kidney disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Optical coherence tomographic retinal differences across stages of chronic kidney disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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