What question did this study set out to answer?

This research aims to measure the thickness of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with chronic kidney disease (CKD).

March 28, 2026CureusOpen Access

Assessment of Retinal Nerve Fiber Layer Changes in Patients With Chronic Kidney Disease: A Cross-Sectional Study

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This research aims to measure the thickness of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with chronic kidney disease (CKD).
Conducted a comparative cross-sectional analysis of 100 CKD patients and 100 healthy controls.
Performed comprehensive ocular examinations including best-corrected visual acuity and intraocular pressure measurements.
Used optical coherence tomography (OCT) to measure RNFL and GCC thickness.
Collected data on CKD duration, serum urea, and creatinine levels.
Analyzed associations using Pearson's coefficient and multivariate analysis.
Statistically significant differences in best-corrected visual acuity and cup-disc ratio were observed between CKD and control groups.
CKD patients had lower mean intraocular pressure compared to controls.
RNFL thickness differed significantly across most quadrants between the two groups.
The ganglion cell complex was thicker in controls in all quadrants except for the inferior quadrant.

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Implication

Cross-sectional study assesses retinal changes in chronic kidney disease, highlighting potential indicators of kidney function.

Cite This Study

Sahu et al. (2026) studied this question.

synapsesocial.com/papers/69c7722a8bbfbc51511e2656 https://doi.org/10.7759/cureus.105875

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Assessment of Retinal Nerve Fiber Layer Changes in Patients With Chronic Kidney Disease: A Cross-Sectional Study

Key Points

Discussion

Implication

Cite This Study

Assessment of Retinal Nerve Fiber Layer Changes in Patients With Chronic Kidney Disease: A Cross-Sectional Study

Key Points

Discussion

Implication

Cite This Study

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