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June 28, 2026Toxicology Mechanisms and Methods

Toxic Effects of Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) on the Gut Microenvironment and Their Potential Association with Colorectal Cancer

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Authors

XTXiufen TangLTLixin Tang

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Overview

Narrative review assesses PFAS effects on gut health and colorectal cancer links, suggesting future research priorities.

Key Points

  • This research evaluates the toxic effects of PFAS on the gut microenvironment and their potential link to colorectal cancer.
  • Integrative review of mechanistic toxicology, multi-omics microbiology, and observational studies.
  • In vitro and animal models were utilized to assess PFAS impact on intestinal barrier function and microbiota.
  • Epidemiological analysis highlights inconsistencies in colorectal cancer associations with PFAS exposure.
  • PFAS exposure disrupted intestinal barrier integrity, increasing permeability and antigen translocation.
  • Altered Wnt/β-catenin signaling observed in colon cell models, linked to cancer-related phenotypes.
  • Microbiome analysis indicated loss of beneficial bacteria and reduced short-chain fatty acids associated with PFAS exposure.

Cite This Study

Tang et al. (2026) studied this question.

synapsesocial.com/papers/6a40bb8b61bb0a67205c6f35https://doi.org/10.1080/15376516.2026.2695156
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