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June 19, 2026Journal of Plastic Film & Sheeting

Gut microbiome-mediated mechanisms of per- and polyfluoroalkyl substances (PFAS) biotransformation and their implications for human health

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Authors

STSeyed Soheil TabibianSSSamira SanamiSASaghar Amirpour

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Overview

Review uncovers mechanisms of PFAS biotransformation in gut microbiome, suggesting health implications for humans.

Key Points

  • The aim is to explore how the gut microbiome alters the behavior and impact of per- and polyfluoroalkyl substances (PFAS) on human health.
  • Evaluated current insights from experimental studies and human cohorts.
  • Reviewed findings from multi-omics approaches including metagenomics and metabolomics.
  • Discussed mechanisms like microbial uptake and enzymatic defluorination.
  • PFAS exposure disrupts microbial diversity and compromises intestinal barrier integrity.
  • Microbiome changes linked to chronic health issues such as inflammation and insulin resistance.
  • Identified potential for microbiome-targeted interventions to mitigate health risks associated with PFAS.

Cite This Study

Tabibian et al. (2026) studied this question.

synapsesocial.com/papers/6a34dec865a5b0777af2e1edhttps://doi.org/10.1177/87560879261462980
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Toxicological Effects and Health Impacts of Per- and Polyfluoroalkyl Substances (PFAS) in Humans2026 · 3 citations
  2. 2Toxic Effects of Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) on the Gut Microenvironment and Their Potential Association with Colorectal Cancer2026
  3. 3Per- and polyfluoroalkyl substances and the human urinary system: Molecular mechanisms, biomarker discovery, and translational perspectives for risk mitigation2026
  4. 4Epidemiological perspectives on PFAS: Environmental fate, health risks, and global mitigation strategies2026 · 3 citations
  5. 5Perfluoroalkyl and Polyfluoroalkyl Substances Exposure and Liver Disease: A Review2026 · 1 citations