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June 19, 2026Ecotoxicology and Environmental SafetyOpen Access

Per- and polyfluoroalkyl substances and the human urinary system: Molecular mechanisms, biomarker discovery, and translational perspectives for risk mitigation

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Authors

LWLijun WanQuzhou City People's HospitalHYHaiyang YuJining UniversityPLPengyu LeiCentral South University of Forestry and Technology

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Overview

Review evaluates PFAS impact on urinary health, identifying biomarkers and suggesting prevention strategies.

Key Points

  • The review aims to explore the molecular mechanisms and health impacts of PFAS exposure on the human urinary system.
  • Evaluated evidence linking PFAS exposure to urinary disorders like chronic kidney disease and benign prostatic hyperplasia.
  • Highlighted PFAS toxic mechanisms including oxidative stress and activation of PI3K-Akt signaling pathway.
  • Discussed potential biomarkers for early detection of PFAS-related urinary diseases.
  • PFAS are linked to various urinary disorders such as chronic kidney disease and acute kidney injury.
  • Oxidative stress markers and inflammatory cytokines can serve as potential biomarkers for assessing PFAS-related urinary health.
  • Identified challenges in existing research, including exposure assessment and need for specific biomarkers.

Cite This Study

Wan et al. (2026) studied this question.

synapsesocial.com/papers/6a34df4a65a5b0777af2e6fahttps://doi.org/10.1016/j.ecoenv.2026.120381
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Kidney Risks Linked to Per‐ and Polyfluoroalkyl Substance Exposure2026
  2. 2Toxicological Effects and Health Impacts of Per- and Polyfluoroalkyl Substances (PFAS) in Humans2026 · 3 citations
  3. 3Gut microbiome-mediated mechanisms of per- and polyfluoroalkyl substances (PFAS) biotransformation and their implications for human health2026
  4. 4Human Exposure Pathways to Per- and Polyfluoroalkyl Substances (PFASs)—A Comprehensive Review of Sources, Physicochemical Properties, and Human Health Risk Assessment2026 · 2 citations
  5. 5The PFAS Health Study: Systematic Literature Review2018 · 55 citations