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September 17, 2026Environmental Toxicology

Kidney Risks Linked to Per‐ and Polyfluoroalkyl Substance Exposure

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Authors

VCVenice Chávez‐ValenciaFLFrancisco Alejandro Lagunas‐Rangel

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Overview

Narrative review reveals adverse kidney outcomes following PFAS exposure in human populations, highlighting heightened disease risk and urgent regulatory needs.

Key Points

  • To synthesize and evaluate current epidemiological and experimental evidence on kidney risks associated with exposure to per- and polyfluoroalkyl substances (PFAS).
  • Reviewed experimental and human epidemiological literature assessing PFAS exposure routes, internal distribution, and renal health endpoints.
  • Analyzed molecular mechanisms of PFAS-induced nephrotoxicity alongside preventive, therapeutic, and regulatory strategies.
  • Identified that PFAS accumulate in renal proximal tubular cells due to inefficient elimination and active reabsorption, leading to sustained cellular injury.
  • Linked PFAS exposure to reduced glomerular filtration rate, accelerated chronic kidney disease progression, and increased risk of nephrolithiasis.
  • Found emerging associations between PFAS exposure and renal cell carcinoma driven by mitochondrial dysfunction, oxidative stress, inflammation, and DNA damage.

Cite This Study

Chávez‐Valencia et al. (2026) studied this question.

synapsesocial.com/papers/6aabb7155f706d05830e5d5chttps://doi.org/10.1002/tox.70197
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  1. 1Per- and polyfluoroalkyl substances and the human urinary system: Molecular mechanisms, biomarker discovery, and translational perspectives for risk mitigation2026
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