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This is a Quantitative Study study (also classified as: Experimental Study).

September 16, 2025Frontiers in EndocrinologyOpen Access

Impact of per- and polyfluoroalkyl substances on diabetic kidney disease

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Systematic evaluation highlights PFAS toxicity consequences in diabetic kidney disease, suggesting potential therapeutic targets.

PFAS exposure contributes to the progression of diabetic kidney disease, implicating critical signaling pathways.
A total of 424 PFAS-associated targets were identified, with links to 9,999 potential toxic targets related to DKD.
Molecular docking simulations reveal strong binding affinities between PFAS compounds and hub proteins, supporting their role in DKD.
This study suggests that PFAS toxicity is connected to immune-mediated renal injury, indicating further research is warranted.

Song et al. (2025) studied this question.

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