Use of Intraarticular Hyaluronic Acid in the Management of Knee Osteoarthritis in Clinical Practice

January 24, 2017Arthritis Care & ResearchOpen Access

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Key Points

To evaluate the efficacy, effectiveness, and safety of intraarticular hyaluronic acid in managing knee osteoarthritis.
Systematic review of randomized controlled trials assessing intraarticular hyaluronic acid.
Comparison of patient outcomes including pain and function after IAHA treatment versus placebo.
Assessment of adverse events related to IAHA administration.
IAHA provided a moderate effect on pain relief with an effect size of 0.34 (95% CI 0.02, 0.67) at 8 weeks.
Patients receiving IA hyaluronic acid reported significantly lower pain scores and enhanced physical function compared to those who did not.
Adverse events were typically mild, with a slight increase in local reactions reported among IAHA recipients (RR 1.08 [95% CI 1.01, 1.15]).

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Shows IA hyaluronic acid improves pain and function in knee osteoarthritis, suggesting its efficacy in treatment.

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Cooper et al. (2017) studied this question.

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