Key result
Acute coronary syndrome was associated with a decrease in platelet count and mean platelet volume at 3 hours, followed by an increase at 72 hours and 7 days only in acute myocardial infarction.
Observational (n=134)
Platelet count and mean platelet volume exhibit biphasic changes in the early phase of acute myocardial infarction, decreasing at 3 hours and increasing by 72 hours.
Serial platelet monitoring may inform AMI risk; extends temporal platelet dynamics beyond admission in ACS.
A strong relationship exists between acute coronary syndrome (ACS) and platelets (PLTs) volume. Mean platelet volume (MPV) is a parameter of PLT functions and a marker for increased PLT activation. The aim of this study was to determine early changes in number of total PLT and MPV in different manifestation of ACS and to find out predictive value of MPV in the spectrum of ACS. This was a prospective study. One hundred thirty-four ACS patients were enrolled, 76 of them finished the study. PLT and MPV in patients with unstable angina, non-ST elevation, and ST elevation myocardial infarctions were determined on arrival and 1, 3, 72 hours, and 7 days after the admission to hospital. There was decrease in PLT and MPV in all three groups after 3 hours of arrival in hospital in comparison with admission values. In the later time period (72 hours and 7 days), there was an increase in PLT and MPV only in patients with acute myocardial infarction (AMI). We have revealed completely new dynamics in early changes in MPV and PLT count in patients with AMI. Biphasic changes were found in early phase after admission to the hospital. Fast response in these parameters raises new questions about their origin.
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Lozo et al. (2017) conducted an observational in Acute Coronary Syndrome (n=134). Acute coronary syndrome vs. Admission values was evaluated on Early changes in number of total PLT and MPV. Acute coronary syndrome was associated with a decrease in platelet count and mean platelet volume at 3 hours, followed by an increase at 72 hours and 7 days only in acute myocardial infarction.
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