Key result
Colchicine demonstrates a beneficial role in preventing pericarditis recurrence, whereas corticosteroids may increase the risk of recurrences.
Why the study?
Does colchicine prevent recurrence in patients with acute and recurring pericarditis compared to corticosteroids?
Does colchicine prevent recurrence in patients with acute and recurring pericarditis compared to corticosteroids?
Colchicine is beneficial for preventing pericarditis recurrence, whereas corticosteroids may increase the risk of recurrence and should be used less.
May warrant caution with select agents in acute pericarditis; leaves open optimal recurrence prevention strategies.
Acute and recurring pericarditis are frequently encountered clinical entities. Given that severe complications such as tamponade and constrictive pericarditis occur rarely, the majority of patients suffering from acute pericarditis will have a benign clinical course. However, pericarditis recurrence, with its painful symptoms, is frequent. In effect, recent studies have demonstrated a beneficial role of colchicine in preventing recurrence, while also suggesting an increase in recurrences with the use of corticosteroids, the traditional first-line agent.
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Paul Farand (2010) conducted a review in Acute and recurring pericarditis. Colchicine vs. Corticosteroids was evaluated on Pericarditis recurrence. Colchicine demonstrates a beneficial role in preventing pericarditis recurrence, whereas corticosteroids may increase the risk of recurrences.
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