Key result
Nitroglycerin and organic nitrates require a daily low-exposure interval to prevent efficacy-limiting tolerance.
This review highlights the mechanisms, clinical applications, and management of tolerance associated with nitroglycerin and organic nitrate therapy in cardiovascular disease.
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Advances understanding of nitrate effects in angina; leaves open whether non-hemodynamic actions should alter practice.
Divakaran et al. (2017) conducted a review in Cardiovascular disease. Nitroglycerin and organic nitrates was evaluated. Nitroglycerin and organic nitrates are widely used for angina, heart failure, and pulmonary hypertension, but their efficacy is limited by tolerance requiring a daily low-exposure interval.
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