Key result
Nitrate therapy is beneficial in angina, myocardial infarction, and congestive heart failure, though intermittent dosing is required to prevent tolerance.
Nitrates provide symptomatic relief in angina and heart failure through vasodilation, but require intermittent dosing to prevent tolerance.
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Supports symptomatic nitrate use with intermittent dosing in angina and HF; leaves open updated RCTs in contemporary care.
Jonathan Abrams (1988) conducted a review in Ischemic heart disease and congestive heart failure. Nitrate therapy was evaluated. Nitrate therapy is beneficial in angina, myocardial infarction, and congestive heart failure, though intermittent dosing is required to prevent tolerance.
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