Organic nitrates are effective for chronic stable angina pectoris, but their therapeutic value is compromised by the rapid development of tolerance during sustained therapy.
This review discusses the use of organic nitrates for chronic stable angina pectoris, highlighting the clinical challenge of nitrate tolerance during sustained therapy.
The organic nitrates are widely used in the management of coronary artery disease. They are given not only to patients with stable angina pectoris, but also to those with unstable angina, acute myocardial infarction, and heart failure. Although they are effective for the treatment of these disorders, their therapeutic value is compromised by the rapid development of tolerance during sustained therapy. This review will be limited to the use of organic nitrates in patients with chronic stable angina pectoris, but many of the principles enunciated are relevant to other clinical situations.In 1879 Murrell reported that a 1 percent solution . . .
Parker et al. (Thu,) conducted a review in chronic stable angina pectoris. organic nitrates was evaluated. Organic nitrates are effective for chronic stable angina pectoris, but their therapeutic value is compromised by the rapid development of tolerance during sustained therapy.