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June 29, 2026Ophthalmology and TherapyOpen Access

Fluorescein Angiography Leakage Patterns in Pachychoroid Neovasculopathy: Neovascularization or Central Serous Chorioretinopathy?

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Authors

SCSoon Il ChoiCCChui Ming Gemmy CheungWLWon Ki Lee

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Overview

Retrospective study characterizes leakage patterns in eyes with pachychoroid neovasculopathy, suggesting implications for treatment response.

Key Points

  • This study aims to describe fluorescein angiography leakage patterns in pachychoroid neovasculopathy and their associations with clinical features and treatment outcomes.
  • Retrospective observational study of patients with pachychoroid neovasculopathy and subretinal fluid at a single center.
  • Analysis of fluorescein angiography, multimodal imaging, and clinical features.
  • Leakage patterns classified as neovascular, central serous chorioretinopathy, or undetermined.
  • 60.56% of eyes exhibited neovascular leakage pattern; 26.76% showed central serous chorioretinopathy pattern.
  • 65.85% of the neovascular pattern group achieved complete subretinal fluid resolution post-VEGF therapy (OR 5.14; 95% CI 1.18-22.49; P=0.037).
  • 71.43% of untreated CSC pattern eyes showed spontaneous resolution, mainly with leakage along the neovascular margin.

Cite This Study

Choi et al. (2026) studied this question.

synapsesocial.com/papers/6a420ab2f91bb43ea9191f51https://doi.org/10.1007/s40123-026-01441-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Choroidal Neovascularization as a Trigger for Central Serous Chorioretinopathy2025
  2. 2Choroidal Neovascularization as a Trigger for Central Serous Chorioretinopathy2025
  3. 3Anatomical and Functional Outcomes of Anti-VEGF Therapy in Pachychoroid Neovasculopathy2025
  4. 4Characteristics and Topographical Distribution of Leaks in Acute Central Serous Chorioretinopathy on Fundus Fluorescein Angiography and Optical Coherence Tomography2025
  5. 5Clinical Features and Optical Coherence Tomography Angiography in Neovascular Age-Related Macular Degeneration and Pachychoroid Neovasculopathy2025