What question did this study set out to answer?

This research aims to investigate how frailty, lifespan, and aging are influenced by sex and strain in mouse models.

The association of frailty with age and lifespan in mice differs by strain and sex

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Randomized trial examines frailty associations with lifespan in mice, suggesting strain and sex significantly influence outcomes.

This research aims to investigate how frailty, lifespan, and aging are influenced by sex and strain in mouse models.
Collated data from 17 independent cohorts involving 1,564 aging mice across five strains.
Included 3,665 observations from cross-sectional and longitudinal studies, with 2,192 linked to known age at death.
Assessed frailty index and lifespan differences by strain and sex.
Frailty index significantly increased with age; however, strain affected the rate of frailty accumulation.
Healthspan and survival showed strain and sex-specific differences, with males generally outliving females.
Strong association between frailty index and lifespan was independent of age, with unique patterns emerging in specific strains.

Zhu et al. (2026) studied this question.

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