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March 18, 2026The Journals of Gerontology Series A

Assessing Health in Aging Male and Female Mice: Does Cardiac Function Dictate Frailty or Physical Resilience?

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Authors

GMGrecia Garcia MarquezGTGeorge E TaffetKCKatarzyna A. Cieslik

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Overview

Assesses cardiac function's role in frailty and resilience for aging mice, suggesting sex-specific interventions are essential.

Key Points

  • The research aims to understand how cardiac function impacts frailty and resilience in aging male and female mice.
  • Animal model comprising aging male and female mice aged 25-26 months.
  • Evaluation using echocardiography and Doppler imaging to assess cardiac parameters.
  • Functional assessments included post-anesthesia recovery time, wire hanging test, and a frailty index.
  • Distinct aging profiles observed: males show frailty linked to cardiac hypertrophy, while females relate recovery to hyperdynamic cardiac markers.
  • Frailty index, recovery time, and wire hanging test results did not correlate, indicating distinct measurement of vulnerability.
  • Significant heterogeneity noted across functional parameters in both male and female mice.

Cite This Study

Marquez et al. (2026) studied this question.

synapsesocial.com/papers/69ba420a4e9516ffd37a1f23https://doi.org/10.1093/gerona/glag075
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