What question did this study set out to answer?

This review aims to evaluate the use of natural deep eutectic solvents in converting citrus byproducts into valuable products.

June 29, 2026Biomass Conversion and Biorefinery0 citationsOpen Access

Natural deep eutectic solvents (Na)DES as green tools for the valorization of citrus byproducts: advances, challenges and perspectives

MVMaria Fernanda Vargas-TorricoUniversidad de Cuautitlán Izcalli EBErich von Borries-MedranoInstituto Politécnico Nacional CGClaudia I. García-BetanzosUniversidad de Cuautitlán Izcalli

Key Points

This review aims to evaluate the use of natural deep eutectic solvents in converting citrus byproducts into valuable products.
Analyzed the properties and classifications of natural deep eutectic solvents (Na)DES.
Explored the coupling of (Na)DES with process-intensification technologies for better extraction outcomes.
Identified challenges in scale-up and proposed solutions for industrial application.
(Na)DES demonstrates reduced processing times and lower solvent consumption compared to hydroethanolic extraction.
Highlights on coupling with techniques like UAE and MAE to enhance yield and selectivity for phenolic compounds and pectin.
Addressed scale-up challenges of high viscosity and solvent recovery, proposing methods like using water as a third component.

Abstract

The citrus industry generates ≈ 50% of byproducts (peel, seeds, pomace) that are rich in polyphenols, flavonoids, terpenoids, and pectins. These bioactives are typically recovered using conventional organic solvents, but these solvents are often toxic, poorly selective, energy-intensive, and generate substantial waste, so there is a clear need for more sustainable options. This review synthesizes the potential of deep eutectic solvents (DES) and their natural variants ((Na)DES) for valorizing citrus residues in the context of a biorefinery. It outlines fundamental aspects and key properties (e.g., polarity, viscosity, and low volatility), classifications, and highlights type III systems (ChCl-based) for their performance-to-cost balance. It also analyzes how coupling with process-intensification technologies (UAE, MAE, PLE) can increase yield and selectivity in the recovery of phenolics and flavonoids (e.g., hesperidin and PMFs), pectin with improved functional attributes (Mw, emulsification), and volatiles (essential oils), through selective fractionation and deterpenation. This approach facilitates co-recovery in a single process train. Compared to hydroethanolic extraction, (Na)DES reduces processing times and solvent consumption and aligns better with the principles of green chemistry. Key scale-up bottlenecks, however, exist in high viscosity, solvent recovery/recycling, and evidence of mixture-level safety (residuals/migration, materials compatibility). Proposed mitigation measures include incorporating water as a third component, operating in continuous mode at moderate temperatures, and utilizing low-energy separations (anti-solvents, membranes, CO₂-switchable DES). Future priorities will center on predictive solvent design (COSMO, QSPR, ML), analytical/toxicological standardization, and comparative TEA/LCA to consolidate industrial adoption across agri-food sector value chains.

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