What does this research mean for the field?

A pyridyl radical-driven dual photoredox catalytic strategy enables the direct two-carbon ring expansion of cyclic thioethers to efficiently synthesize sulfur-containing semisaturated fused pyridines. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to develop a catalytic method for expanding cyclic thioethers into complex semisaturated fused pyridines.

June 29, 2026Journal of the American Chemical Society

Pyridyl Radical-Induced Catalytic Reconstruction of Cyclic Sulfides

View Full Paper

Ask AI

Bookmark

Authors

YLYi-Peng LiuSun Yat-sen University SGShi-Yu GuoDalian Institute of Chemical Physics ZDZhi-Yuan DingDalian Institute of Chemical Physics

Discussion

Member takes

Implication

Randomized trial demonstrates efficient ring expansion in cyclic thioethers, indicating a new strategy for heterocycle synthesis.

Key Points

The aim is to develop a catalytic method for expanding cyclic thioethers into complex semisaturated fused pyridines.
Utilized pyridyl radical-driven catalytic strategy for ring expansion.
Implemented dual photoredox cycles for radical transformations.
Conducted mechanistic studies supporting the stepwise radical process.
Achieved efficient synthesis of semisaturated fused pyridines.
Demonstrated broad functional-group tolerance and substrate generality.
Enabled gram-scale synthesis and late-stage modifications of pharmaceutical compounds.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a420adff91bb43ea91921e5 https://doi.org/10.1021/jacs.6c09452

View Full Paper

Ask AI

Bookmark

Pyridyl Radical-Induced Catalytic Reconstruction of Cyclic Sulfides

Discussion

Member takes

Implication

Key Points

Cite This Study

Pyridyl Radical-Induced Catalytic Reconstruction of Cyclic Sulfides

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider