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November 21, 2025European Journal of Organic Chemistry

Modular Assembly of Cyclic Sulfones via Radical Annulation with Unactivated Olefins

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Authors

YZYifei ZhaoXWXuanchi WangXLXinlian Liu

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Overview

This work demonstrates tunable synthesis of cyclic sulfones in drug discovery, suggesting potential for diverse bioactive molecules.

Key Points

  • Cyclic sulfones were synthesized via radical annulation with unactivated olefins and sulfonylmethyl bromides.
  • Incorporating photoredox catalysis, this method enhances synthetic efficiency and structural diversity.
  • The approach revealed a radical relay cyclization mechanism that offers insights into the synthesis process.
  • The method's capability is evidenced by effective synthesis of several bioactive molecules with cyclic sulfone structures.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/6924e405c0ce034ddc34f888https://doi.org/10.1002/ejoc.202501044
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