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June 27, 2026International Reviews of Immunology

Metabolic alterations in the tumor microenvironment influence the anti-tumor immune function of CD8 ⁺ T cells via epigenetic modifications

Yaru Liu Wei Du Weimin Deng

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Key Points

To explore how metabolic changes in the tumor microenvironment affect the immune function of CD8+ T cells through epigenetic modifications.
Investigated metabolic alterations within the tumor environment
Analyzed CD8+ T cell responses and function
Examined epigenetic changes related to T cell activation
Metabolic alterations led to significant epigenetic modifications in CD8+ T cells
Enhanced anti-tumor immunity observed in genetically modified T cells
Potential pathways identified for improving cancer therapies through immune modulation

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Implication

Demonstrates metabolic influences on CD8 T cell anti-tumor immunity, suggesting novel therapeutic avenues.

Abstract

T cell anti-tumor immunity, offering novel perspectives for enhancing adoptive cell therapy and immune checkpoint blockade.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a420b08f91bb43ea91922f0 https://doi.org/10.1080/08830185.2026.2687543

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